The biggest questions for me are Nixa and Republic. They were both very good last year and both lost a ton. Nixa has a great coach and an enormous talent pool and has been very good in upcoming classes. So has Republic. So they could take a page from Webb City's playbook and just simply "reload". Or they may be good but not great.
I think Carthage will be pretty good, maybe very good. Almost everyone is returning so they will have more experience than most teams. On the other hand it's basically the same team as last year which had some serious flaws.
Webb City without their best player is unfortunate but they still have a ton of depth and I think they will be good enough to beat or at least hang with anyone on their schedule.