I'm not a coach or a football expert but I would say yes it could. It seems like there is usually only one or two a game that really hurt.
The one at the start of the 3rd quarter in my opinion completely changed the flow of the game. To that point Lamar had looked good on D, only giving up one score, and was marching. We score on a big play going into half, received after the break, and immediately drove down to the Ava 19 with no issue. Looks like we will easily go up 28-8, and all of the momentum. Instead there's a holding deep in the backfield to push it to 1st and 20 something... can't convert, missed FG, then Ava immediately drives and scores. What should have been a 3 possession game was a one possession game in a matter of minutes.